SEZ6 and Neuronal Calcium Signalling in Synapse Development

Grant number: 1008046 | Funding period: 2011 - 2014

Completed

Abstract

Inappropriate development and function of neuronal circuits is a universal feature of neurological disorders of cognition such as Down syndrome, autism spectrum disorders and Fragile X mental retardation, epilepsy, schizophrenia and Alzheimerï¿1⁄2s disease. In these diseases, neurons exhibit abnormal neuronal branches (dendrites) and abnormal connections on dendritic spines. This research is aimed at understanding the mechanisms controlling dendrite development that underpin proper neuronal wiring.

Related publications (3)

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6

K Zhu, X Xiang, S Filser, P Marinković, MM Dorostkar, S Crux, U Neumann, DR Shimshek, G Rammes, C Haass, SF Lichtenthaler, JM Gunnersen, J Herms

2018-03-01

Background: Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a promising drug target for the treatment of Alzheime..

Seizure-6 proteins highlight BACE1 functions in neurobiology

M Pigoni, J GUNNERSEN, SF Lichtenthaler

2016-01-01

Differential labeling of cell-surface and internalized proteins after antibody feeding of live cultured neurons

NL Carrodus, KSL Teng, KM Munro, MJ Kennedy, JM Gunnersen

2014-02-12

In order to demonstrate the cell-surface localization of a putative transmembrane receptor in cultured neurons, we labeled the pro..

University of Melbourne Researchers

Jenny Gunnersen